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Upstream Bio, Inc. Share Price

UPB

NSQ

$30.16

+$0.22

(0.73%)

Industry: Biotechnology Sector: Health Care

Upstream Bio, Inc. Analyst Forecast

Overview Returns Financials Ratios News FAQs

Upstream Bio, Inc. Share Price Chart

Upstream Bio, Inc. Key Stock Metrics

Market Cap info-icon

This is a company’s total value as determined by the stock market. It is calculated by multiplying the total number of a company's outstanding shares by the current market price of one share.

$1.62B

P/E Ratio

This is the ratio of a security’s current share price to its earnings per share. This ratio determines the relative value of a company’s share.

Volume

This is the total number of shares traded during the most recent trading day.

56.78K

Avg Volume info-icon

This is the average number of shares traded during the most recent 30 days.

Dividend Yield info-icon

This ratio shows how much income you earn in dividend payouts per year for every dollar invested in the stock (or the stock’s annual dividend payment expressed as a percentage of its current price).

0.00%

Beta

This measures the expected move in a stock’s price relative to movements in the overall market. The market, such as the S&P 500 Index, has a beta of 1.0. If a stock has a Beta greater (or lower) than 1.0, it suggests that the stock is more (or less) volatile than the broader market.

52-week Range info-icon

This shows the range of the stock’s price between the 52-week high (the highest price of the stock for the past 52 weeks) and the 52-week low (the lowest price of the stock for the past 52 weeks).

$5.14 L

$33.68 H

$30.16

About Upstream Bio, Inc., Common Stock

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 clinical development for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps, and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts. more

Industry: BiotechnologySector: Health Care

Upstream Bio, Inc. Stock Returns

Time Frame	UPB	Sector	S&P500
1-Week Return	-0.73%	-1.52%	0.41%
1-Month Return	10.6%	0.12%	1.81%
3-Month Return	19.66%	7.78%	1.82%
6-Month Return	91.8%	17.05%	10.26%
1-Year Return	201.51%	5.6%	16.37%
3-Year Return	76.12%	16.99%	67.04%

Time Frame	UPB	Sector	S&P500
1-Week Return	-31.75%	-55.01%	23.78%
1-Month Return	240.69%	1.47%	24.39%
3-Month Return	107.07%	35.51%	7.59%
6-Month Return	274.59%	37.61%	21.90%
1-Year Return	201.51%	5.60%	16.37%
3-Year Return	20.76%	5.37%	18.65%

Upstream Bio, Inc. Financials

	Dec '22	Dec '23	Dec '24
Total Revenue	1.21M	2.38M	2.37M	[{"date":"2022-12-31","value":50.92,"profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":99.58,"profit":true}]
Cost of Revenue	7.00K	60.00K	89.00K	[{"date":"2022-12-31","value":7.87,"profit":true},{"date":"2023-12-31","value":67.42,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Gross Profit	1.21M	2.38M	2.37M	[{"date":"2022-12-31","value":50.92,"profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":99.58,"profit":true}]
Gross Margin	100.00%	100.00%	100.00%	[{"date":"2022-12-31","value":100,"profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]

Operating Expenses	25.12M	42.49M	80.13M	[{"date":"2022-12-31","value":31.35,"profit":true},{"date":"2023-12-31","value":53.03,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Operating Income	(23.91M)	(40.11M)	(77.76M)	[{"date":"2022-12-31","value":-2390900000,"profit":false},{"date":"2023-12-31","value":-4011400000,"profit":false},{"date":"2024-12-31","value":-7776400000,"profit":false}]
Total Non-Operating Income/Expense	246.00K	23.74M	27.08M	[{"date":"2022-12-31","value":0.91,"profit":true},{"date":"2023-12-31","value":87.67,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Pre-Tax Income	(23.87M)	(20.54M)	(62.81M)	[{"date":"2022-12-31","value":-2386800000,"profit":false},{"date":"2023-12-31","value":-2053700000,"profit":false},{"date":"2024-12-31","value":-6280600000,"profit":false}]
Income Taxes	-	-	-	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true}]
Income After Taxes	-	-	-	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true}]

Income From Continuous Operations	(23.87M)	(20.54M)	(62.81M)	[{"date":"2022-12-31","value":-2386800000,"profit":false},{"date":"2023-12-31","value":-2053700000,"profit":false},{"date":"2024-12-31","value":-6280600000,"profit":false}]
Income From Discontinued Operations	-	-	-	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true}]
Net Income	(23.87M)	(20.54M)	(62.81M)	[{"date":"2022-12-31","value":-2386800000,"profit":false},{"date":"2023-12-31","value":-2053700000,"profit":false},{"date":"2024-12-31","value":-6280600000,"profit":false}]

EPS (Diluted)	-	-	(18.55)	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":-1855,"profit":false}]

	Dec '22	Dec '23	Dec '24
Total Revenue	-	96.37%	(0.42%)	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":-0.44,"profit":false}]
Cost of Revenue	-	757.14%	48.33%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":6.38,"profit":true}]
Gross Profit	-	96.37%	(0.42%)	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":-0.44,"profit":false}]
Gross Margin	-	-	-	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true}]

Operating Expenses	-	69.16%	88.58%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":78.08,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Operating Income	-	67.78%	93.86%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":72.21,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Total Non-Operating Income/Expense	-	9551.22%	14.06%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":0.15,"profit":true}]
Pre-Tax Income	-	(13.96%)	205.82%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":-6.78,"profit":false},{"date":"2024-12-31","value":100,"profit":true}]
Income Taxes	-	-	-	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true}]
Income After Taxes	-	-	-	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true}]

Income From Continuous Operations	-	(13.96%)	205.82%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":-6.78,"profit":false},{"date":"2024-12-31","value":100,"profit":true}]
Income From Discontinued Operations	-	-	-	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true}]
Net Income	-	(13.96%)	205.82%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":-6.78,"profit":false},{"date":"2024-12-31","value":100,"profit":true}]

EPS (Diluted)	-	-	-	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true}]

	Sep '24	Dec '24	Mar '25	Jun '25	Sep '25	TREND
Total Revenue	607.00K	613.00K	566.00K	937.00K	683.00K	[{"date":"2024-09-30","value":64.78,"profit":true},{"date":"2024-12-31","value":65.42,"profit":true},{"date":"2025-03-31","value":60.41,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":72.89,"profit":true}]
Cost of Revenue	14.00K	49.00K	43.00K	57.00K	31.00K	[{"date":"2024-09-30","value":24.56,"profit":true},{"date":"2024-12-31","value":85.96,"profit":true},{"date":"2025-03-31","value":75.44,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":54.39,"profit":true}]
Gross Profit	607.00K	613.00K	566.00K	937.00K	652.00K	[{"date":"2024-09-30","value":64.78,"profit":true},{"date":"2024-12-31","value":65.42,"profit":true},{"date":"2025-03-31","value":60.41,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":69.58,"profit":true}]
Gross Margin	100.00%	100.00%	100.00%	100.00%	95.46%	[{"date":"2024-09-30","value":100,"profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":100,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":95.46,"profit":true}]

Operating Expenses	19.50M	26.93M	32.58M	45.28M	38.49M	[{"date":"2024-09-30","value":43.06,"profit":true},{"date":"2024-12-31","value":59.47,"profit":true},{"date":"2025-03-31","value":71.94,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":84.99,"profit":true}]
Operating Income	(18.89M)	(26.32M)	(32.01M)	(44.35M)	(37.83M)	[{"date":"2024-09-30","value":-1889300000,"profit":false},{"date":"2024-12-31","value":-2631800000,"profit":false},{"date":"2025-03-31","value":-3201300000,"profit":false},{"date":"2025-06-30","value":-4434700000,"profit":false},{"date":"2025-09-30","value":-3783400000,"profit":false}]
Total Non-Operating Income/Expense	5.80M	10.15M	9.49M	8.81M	8.19M	[{"date":"2024-09-30","value":57.18,"profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":93.44,"profit":true},{"date":"2025-06-30","value":86.8,"profit":true},{"date":"2025-09-30","value":80.68,"profit":true}]
Pre-Tax Income	(15.99M)	(21.24M)	(27.27M)	(39.97M)	(33.75M)	[{"date":"2024-09-30","value":-1599200000,"profit":false},{"date":"2024-12-31","value":-2124200000,"profit":false},{"date":"2025-03-31","value":-2727000000,"profit":false},{"date":"2025-06-30","value":-3996600000,"profit":false},{"date":"2025-09-30","value":-3374800000,"profit":false}]
Income Taxes	-	-	-	-	-	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true},{"date":"2025-03-31","value":"-","profit":true},{"date":"2025-06-30","value":"-","profit":true},{"date":"2025-09-30","value":"-","profit":true}]
Income After Taxes	-	-	-	-	-	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true},{"date":"2025-03-31","value":"-","profit":true},{"date":"2025-06-30","value":"-","profit":true},{"date":"2025-09-30","value":"-","profit":true}]

Income From Continuous Operations	(15.99M)	(21.24M)	(27.27M)	(39.97M)	(33.75M)	[{"date":"2024-09-30","value":-1599200000,"profit":false},{"date":"2024-12-31","value":-2124200000,"profit":false},{"date":"2025-03-31","value":-2727000000,"profit":false},{"date":"2025-06-30","value":-3996600000,"profit":false},{"date":"2025-09-30","value":-3374800000,"profit":false}]
Income From Discontinued Operations	-	-	-	-	-	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true},{"date":"2025-03-31","value":"-","profit":true},{"date":"2025-06-30","value":"-","profit":true},{"date":"2025-09-30","value":"-","profit":true}]
Net Income	(15.99M)	(21.24M)	(27.27M)	(39.97M)	(33.75M)	[{"date":"2024-09-30","value":-1599200000,"profit":false},{"date":"2024-12-31","value":-2124200000,"profit":false},{"date":"2025-03-31","value":-2727000000,"profit":false},{"date":"2025-06-30","value":-3996600000,"profit":false},{"date":"2025-09-30","value":-3374800000,"profit":false}]

EPS (Diluted)	(6.96)	(0.41)	(0.51)	(0.74)	(0.63)	[{"date":"2024-09-30","value":-696,"profit":false},{"date":"2024-12-31","value":-41,"profit":false},{"date":"2025-03-31","value":-51,"profit":false},{"date":"2025-06-30","value":-74,"profit":false},{"date":"2025-09-30","value":-63,"profit":false}]

	Sep '24	Dec '24	Mar '25	Jun '25	Sep '25	TREND
Total Revenue	-	0.99%	(7.67%)	65.55%	(27.11%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":1.51,"profit":true},{"date":"2025-03-31","value":-11.7,"profit":false},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":-41.36,"profit":false}]
Cost of Revenue	-	250.00%	(12.24%)	32.56%	(45.61%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":-4.9,"profit":false},{"date":"2025-06-30","value":13.02,"profit":true},{"date":"2025-09-30","value":-18.25,"profit":false}]
Gross Profit	-	0.99%	(7.67%)	65.55%	(30.42%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":1.51,"profit":true},{"date":"2025-03-31","value":-11.7,"profit":false},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":-46.4,"profit":false}]
Gross Margin	-	-	-	-	(4.54%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true},{"date":"2025-03-31","value":"-","profit":true},{"date":"2025-06-30","value":"-","profit":true},{"date":"2025-09-30","value":null,"profit":false}]

Operating Expenses	-	38.11%	20.97%	39.00%	(15.01%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":97.72,"profit":true},{"date":"2025-03-31","value":53.78,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":-38.49,"profit":false}]
Operating Income	-	39.30%	21.64%	38.53%	(14.69%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":55.06,"profit":true},{"date":"2025-06-30","value":98.04,"profit":true},{"date":"2025-09-30","value":-37.37,"profit":false}]
Total Non-Operating Income/Expense	-	74.88%	(6.56%)	(7.11%)	(7.05%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":-8.76,"profit":false},{"date":"2025-06-30","value":-9.49,"profit":false},{"date":"2025-09-30","value":-9.41,"profit":false}]
Pre-Tax Income	-	32.83%	28.38%	46.56%	(15.56%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":70.51,"profit":true},{"date":"2025-03-31","value":60.95,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":-33.42,"profit":false}]
Income Taxes	-	-	-	-	-	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true},{"date":"2025-03-31","value":"-","profit":true},{"date":"2025-06-30","value":"-","profit":true},{"date":"2025-09-30","value":"-","profit":true}]
Income After Taxes	-	-	-	-	-	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true},{"date":"2025-03-31","value":"-","profit":true},{"date":"2025-06-30","value":"-","profit":true},{"date":"2025-09-30","value":"-","profit":true}]

Income From Continuous Operations	-	32.83%	28.38%	46.56%	(15.56%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":70.51,"profit":true},{"date":"2025-03-31","value":60.95,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":-33.42,"profit":false}]
Income From Discontinued Operations	-	-	-	-	-	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":"-","profit":true},{"date":"2025-03-31","value":"-","profit":true},{"date":"2025-06-30","value":"-","profit":true},{"date":"2025-09-30","value":"-","profit":true}]
Net Income	-	32.83%	28.38%	46.56%	(15.56%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":70.51,"profit":true},{"date":"2025-03-31","value":60.95,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":-33.42,"profit":false}]

EPS (Diluted)	-	(94.11%)	24.39%	45.10%	(14.86%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":-208.68,"profit":false},{"date":"2025-03-31","value":54.08,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":-32.96,"profit":false}]

	Dec '22	Dec '23	Dec '24
Total Assets
Current Assets	18.31M	117.00M	479.16M	[{"date":"2022-12-31","value":3.82,"profit":true},{"date":"2023-12-31","value":24.42,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Non-current Assets	171.00K	202.00K	2.56M	[{"date":"2022-12-31","value":6.68,"profit":true},{"date":"2023-12-31","value":7.89,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Total Assets	18.48M	117.20M	481.72M	[{"date":"2022-12-31","value":3.84,"profit":true},{"date":"2023-12-31","value":24.33,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]

Total Liabilities
Current Liabilities	4.86M	6.51M	10.74M	[{"date":"2022-12-31","value":45.23,"profit":true},{"date":"2023-12-31","value":60.68,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Non-current Liabilities	119.78M	233.81M	1.13M	[{"date":"2022-12-31","value":51.23,"profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":0.48,"profit":true}]
Total Liabilities	124.63M	240.32M	11.87M	[{"date":"2022-12-31","value":51.86,"profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":4.94,"profit":true}]

Total Shareholders' equity
Common Stock	3.00K	3.00K	53.00K	[{"date":"2022-12-31","value":5.66,"profit":true},{"date":"2023-12-31","value":5.66,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Retained Earnings	(107.44M)	(127.97M)	(190.78M)	[{"date":"2022-12-31","value":-10743700000,"profit":false},{"date":"2023-12-31","value":-12797400000,"profit":false},{"date":"2024-12-31","value":-19078000000,"profit":false}]
Other Stockholders' Equity	1.28M	4.82M	660.60M	[{"date":"2022-12-31","value":0.19,"profit":true},{"date":"2023-12-31","value":0.73,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Total Shareholders' equity	(106.16M)	(123.13M)	469.85M	[{"date":"2022-12-31","value":-22.59,"profit":false},{"date":"2023-12-31","value":-26.21,"profit":false},{"date":"2024-12-31","value":100,"profit":true}]

Total Liabilities & Shareholders Equity	18.48M	117.20M	481.72M	[{"date":"2022-12-31","value":3.84,"profit":true},{"date":"2023-12-31","value":24.33,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]

	Dec '22	Dec '23	Dec '24
Total Assets
Current Assets	-	539.08%	309.55%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":57.42,"profit":true}]
Non-current Assets	-	18.13%	1166.83%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":1.55,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Total Assets	-	534.26%	311.03%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":58.22,"profit":true}]

Total Liabilities
Current Liabilities	-	34.16%	64.80%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":52.72,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Non-current Liabilities	-	95.20%	(99.52%)	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":-104.53,"profit":false}]
Total Liabilities	-	92.83%	(95.06%)	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":-102.41,"profit":false}]

Total Shareholders' equity
Common Stock	-	-	1666.67%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Retained Earnings	-	19.12%	49.08%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":38.95,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Other Stockholders' Equity	-	277.17%	13594.11%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":2.04,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]
Total Shareholders' equity	-	15.99%	(481.60%)	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":-3012.46,"profit":false}]

Total Liabilities & Shareholders Equity	-	534.26%	311.03%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":58.22,"profit":true}]

	Sep '24	Dec '24	Mar '25	Jun '25	Sep '25	TREND
Total Assets
Current Assets	227.27M	479.16M	453.79M	418.27M	389.02M	[{"date":"2024-09-30","value":47.43,"profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":94.7,"profit":true},{"date":"2025-06-30","value":87.29,"profit":true},{"date":"2025-09-30","value":81.19,"profit":true}]
Non-current Assets	5.43M	2.56M	2.38M	2.25M	2.18M	[{"date":"2024-09-30","value":100,"profit":true},{"date":"2024-12-31","value":47.15,"profit":true},{"date":"2025-03-31","value":43.89,"profit":true},{"date":"2025-06-30","value":41.44,"profit":true},{"date":"2025-09-30","value":40.13,"profit":true}]
Total Assets	232.70M	481.72M	456.17M	420.52M	391.19M	[{"date":"2024-09-30","value":48.31,"profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":94.7,"profit":true},{"date":"2025-06-30","value":87.3,"profit":true},{"date":"2025-09-30","value":81.21,"profit":true}]

Total Liabilities
Current Liabilities	10.87M	10.74M	9.57M	10.93M	11.91M	[{"date":"2024-09-30","value":91.32,"profit":true},{"date":"2024-12-31","value":90.17,"profit":true},{"date":"2025-03-31","value":80.34,"profit":true},{"date":"2025-06-30","value":91.78,"profit":true},{"date":"2025-09-30","value":100,"profit":true}]
Non-current Liabilities	382.14M	1.13M	992.00K	849.00K	703.00K	[{"date":"2024-09-30","value":100,"profit":true},{"date":"2024-12-31","value":0.3,"profit":true},{"date":"2025-03-31","value":0.26,"profit":true},{"date":"2025-06-30","value":0.22,"profit":true},{"date":"2025-09-30","value":0.18,"profit":true}]
Total Liabilities	393.01M	11.87M	10.56M	11.78M	12.61M	[{"date":"2024-09-30","value":100,"profit":true},{"date":"2024-12-31","value":3.02,"profit":true},{"date":"2025-03-31","value":2.69,"profit":true},{"date":"2025-06-30","value":3,"profit":true},{"date":"2025-09-30","value":3.21,"profit":true}]

Total Shareholders' equity
Common Stock	3.00K	53.00K	53.00K	54.00K	56.00K	[{"date":"2024-09-30","value":5.36,"profit":true},{"date":"2024-12-31","value":94.64,"profit":true},{"date":"2025-03-31","value":94.64,"profit":true},{"date":"2025-06-30","value":96.43,"profit":true},{"date":"2025-09-30","value":100,"profit":true}]
Retained Earnings	(169.54M)	(190.78M)	(218.05M)	(258.02M)	(291.76M)	[{"date":"2024-09-30","value":-16953800000,"profit":false},{"date":"2024-12-31","value":-19078000000,"profit":false},{"date":"2025-03-31","value":-21805000000,"profit":false},{"date":"2025-06-30","value":-25801600000,"profit":false},{"date":"2025-09-30","value":-29176400000,"profit":false}]
Other Stockholders' Equity	8.87M	660.60M	663.24M	666.45M	669.80M	[{"date":"2024-09-30","value":1.32,"profit":true},{"date":"2024-12-31","value":98.63,"profit":true},{"date":"2025-03-31","value":99.02,"profit":true},{"date":"2025-06-30","value":99.5,"profit":true},{"date":"2025-09-30","value":100,"profit":true}]
Total Shareholders' equity	(160.31M)	469.85M	445.61M	408.74M	378.58M	[{"date":"2024-09-30","value":-34.12,"profit":false},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":94.84,"profit":true},{"date":"2025-06-30","value":86.99,"profit":true},{"date":"2025-09-30","value":80.58,"profit":true}]

Total Liabilities & Shareholders Equity	232.70M	481.72M	456.17M	420.52M	391.19M	[{"date":"2024-09-30","value":48.31,"profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":94.7,"profit":true},{"date":"2025-06-30","value":87.3,"profit":true},{"date":"2025-09-30","value":81.21,"profit":true}]

	Sep '24	Dec '24	Mar '25	Jun '25	Sep '25	TREND
Total Assets
Current Assets	-	110.83%	(5.30%)	(7.83%)	(6.99%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":-4.78,"profit":false},{"date":"2025-06-30","value":-7.06,"profit":false},{"date":"2025-09-30","value":-6.31,"profit":false}]
Non-current Assets	-	(52.85%)	(6.92%)	(5.58%)	(3.16%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":null,"profit":false},{"date":"2025-03-31","value":null,"profit":false},{"date":"2025-06-30","value":null,"profit":false},{"date":"2025-09-30","value":null,"profit":false}]
Total Assets	-	107.01%	(5.30%)	(7.81%)	(6.97%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":-4.96,"profit":false},{"date":"2025-06-30","value":-7.3,"profit":false},{"date":"2025-09-30","value":-6.52,"profit":false}]

Total Liabilities
Current Liabilities	-	(1.26%)	(10.90%)	14.24%	8.96%	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":-8.85,"profit":false},{"date":"2025-03-31","value":-76.54,"profit":false},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":62.92,"profit":true}]
Non-current Liabilities	-	(99.70%)	(12.21%)	(14.42%)	(17.20%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":null,"profit":false},{"date":"2025-03-31","value":null,"profit":false},{"date":"2025-06-30","value":null,"profit":false},{"date":"2025-09-30","value":null,"profit":false}]
Total Liabilities	-	(96.98%)	(11.02%)	11.54%	7.07%	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":-840.05,"profit":false},{"date":"2025-03-31","value":-95.47,"profit":false},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":61.26,"profit":true}]

Total Shareholders' equity
Common Stock	-	1666.67%	-	1.89%	3.70%	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":"-","profit":true},{"date":"2025-06-30","value":0.11,"profit":true},{"date":"2025-09-30","value":0.22,"profit":true}]
Retained Earnings	-	12.53%	14.29%	18.33%	13.08%	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":68.36,"profit":true},{"date":"2025-03-31","value":77.99,"profit":true},{"date":"2025-06-30","value":100,"profit":true},{"date":"2025-09-30","value":71.36,"profit":true}]
Other Stockholders' Equity	-	7345.10%	0.40%	0.48%	0.50%	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":0.01,"profit":true},{"date":"2025-06-30","value":0.01,"profit":true},{"date":"2025-09-30","value":0.01,"profit":true}]
Total Shareholders' equity	-	(393.09%)	(5.16%)	(8.27%)	(7.38%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":null,"profit":false},{"date":"2025-03-31","value":null,"profit":false},{"date":"2025-06-30","value":null,"profit":false},{"date":"2025-09-30","value":null,"profit":false}]

Total Liabilities & Shareholders Equity	-	107.01%	(5.30%)	(7.81%)	(6.97%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":-4.96,"profit":false},{"date":"2025-06-30","value":-7.3,"profit":false},{"date":"2025-09-30","value":-6.52,"profit":false}]

	Dec '22	Dec '23	Dec '24
Operating Activities
Net Operating Cash Flow	(19.02M)	(37.93M)	(59.17M)	[{"date":"2022-12-31","value":-1902100000,"profit":false},{"date":"2023-12-31","value":-3792600000,"profit":false},{"date":"2024-12-31","value":-5917200000,"profit":false}]

Investing Activities
Net Investing Cash Flow	(82.00K)	(82.84M)	(59.48M)	[{"date":"2022-12-31","value":-8200000,"profit":false},{"date":"2023-12-31","value":-8284200000,"profit":false},{"date":"2024-12-31","value":-5948500000,"profit":false}]

Financing Activities
Net Financing Cash Flow	9.96M	129.55M	418.91M	[{"date":"2022-12-31","value":2.38,"profit":true},{"date":"2023-12-31","value":30.93,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]

Net Change in Cash	(9.14M)	8.78M	300.25M	[{"date":"2022-12-31","value":-3.04,"profit":false},{"date":"2023-12-31","value":2.92,"profit":true},{"date":"2024-12-31","value":100,"profit":true}]

Free Cash Flow
Free Cash Flow	(19.10M)	(38.07M)	(59.68M)	[{"date":"2022-12-31","value":-1910300000,"profit":false},{"date":"2023-12-31","value":-3807000000,"profit":false},{"date":"2024-12-31","value":-5968300000,"profit":false}]

	Dec '22	Dec '23	Dec '24
Operating Activities
Net Operating Cash Flow	-	99.39%	56.02%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":56.36,"profit":true}]

Investing Activities
Net Investing Cash Flow	-	100926.83%	(28.19%)	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":-0.03,"profit":false}]

Financing Activities
Net Financing Cash Flow	-	1200.31%	223.36%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":18.61,"profit":true}]

Net Change in Cash	-	(196.08%)	3318.96%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":-5.91,"profit":false},{"date":"2024-12-31","value":100,"profit":true}]

Free Cash Flow
Free Cash Flow	-	99.29%	56.77%	[{"date":"2022-12-31","value":"-","profit":true},{"date":"2023-12-31","value":100,"profit":true},{"date":"2024-12-31","value":57.18,"profit":true}]

	Sep '24	Dec '24	Mar '25	Jun '25	Sep '25	TREND
Operating Activities
Net Operating Cash Flow	(13.96M)	(19.61M)	(41.16M)	(39.24M)	(22.24M)	[{"date":"2024-09-30","value":-1396200000,"profit":false},{"date":"2024-12-31","value":-1961200000,"profit":false},{"date":"2025-03-31","value":-4116500000,"profit":false},{"date":"2025-06-30","value":-3923900000,"profit":false},{"date":"2025-09-30","value":-2224000000,"profit":false}]

Investing Activities
Net Investing Cash Flow	1.41M	41.91M	(213.38M)	12.77M	48.19M	[{"date":"2024-09-30","value":2.92,"profit":true},{"date":"2024-12-31","value":86.97,"profit":true},{"date":"2025-03-31","value":-442.83,"profit":false},{"date":"2025-06-30","value":26.51,"profit":true},{"date":"2025-09-30","value":100,"profit":true}]

Financing Activities
Net Financing Cash Flow	(1.64M)	270.65M	(34.00K)	612.00K	760.00K	[{"date":"2024-09-30","value":-0.61,"profit":false},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":-0.01,"profit":false},{"date":"2025-06-30","value":0.23,"profit":true},{"date":"2025-09-30","value":0.28,"profit":true}]

Net Change in Cash	(14.19M)	292.94M	(254.58M)	(25.85M)	26.71M	[{"date":"2024-09-30","value":-4.85,"profit":false},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":-86.9,"profit":false},{"date":"2025-06-30","value":-8.83,"profit":false},{"date":"2025-09-30","value":9.12,"profit":true}]

Free Cash Flow
Free Cash Flow	(14.29M)	(19.80M)	(41.16M)	(39.29M)	(22.29M)	[{"date":"2024-09-30","value":-1428800000,"profit":false},{"date":"2024-12-31","value":-1979700000,"profit":false},{"date":"2025-03-31","value":-4116500000,"profit":false},{"date":"2025-06-30","value":-3928600000,"profit":false},{"date":"2025-09-30","value":-2228700000,"profit":false}]

	Sep '24	Dec '24	Mar '25	Jun '25	Sep '25	TREND
Operating Activities
Net Operating Cash Flow	-	40.47%	109.90%	(4.68%)	(43.32%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":36.82,"profit":true},{"date":"2025-03-31","value":100,"profit":true},{"date":"2025-06-30","value":-4.26,"profit":false},{"date":"2025-09-30","value":-39.42,"profit":false}]

Investing Activities
Net Investing Cash Flow	-	2874.31%	(609.17%)	(105.99%)	277.25%	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":100,"profit":true},{"date":"2025-03-31","value":-21.19,"profit":false},{"date":"2025-06-30","value":-3.69,"profit":false},{"date":"2025-09-30","value":9.65,"profit":true}]

Financing Activities
Net Financing Cash Flow	-	(16592.87%)	(100.01%)	(1900.00%)	24.18%	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":-68613.76,"profit":false},{"date":"2025-03-31","value":-413.57,"profit":false},{"date":"2025-06-30","value":-7856.76,"profit":false},{"date":"2025-09-30","value":100,"profit":true}]

Net Change in Cash	-	(2163.86%)	(186.90%)	(89.84%)	(203.30%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":null,"profit":false},{"date":"2025-03-31","value":null,"profit":false},{"date":"2025-06-30","value":null,"profit":false},{"date":"2025-09-30","value":null,"profit":false}]

Free Cash Flow
Free Cash Flow	-	38.56%	107.94%	(4.56%)	(43.27%)	[{"date":"2024-09-30","value":"-","profit":true},{"date":"2024-12-31","value":35.72,"profit":true},{"date":"2025-03-31","value":100,"profit":true},{"date":"2025-06-30","value":-4.23,"profit":false},{"date":"2025-09-30","value":-40.09,"profit":false}]

Upstream Bio, Inc. Ratios

Upstream Bio, Inc. Liquidity Ratios

These ratios help you determine the liquidity of the company. Higher is better.

	UPB
Cash Ratio	31.28
Current Ratio	32.67

Upstream Bio, Inc. Asset Efficiency Ratios

These ratios help you understand the company's efficiency in using its assets to generate returns. Higher is better. For ROE, average long term is around 14%, less than 10% is poor.

	UPB
ROA (LTM)	-28.15%
ROE (LTM)	-40.80%

Upstream Bio, Inc. Liability Ratios

These ratios help you understand the company's liabilities, gauging the riskiness of the investment.

	UPB
Debt Ratio Lower is generally better. Negative is bad.	0.03
Common Equity/Total Assets Higher is better. Lower can suggest investment is riskier.	0.97

Upstream Bio, Inc. Valuation Ratios

These ratios help you understand the company's valuation. Lower may indicate cheaper stocks.

	UPB
Trailing PE	NM
Forward PE	NM
P/S (TTM)	600.04
P/B	4.44
Price/FCF	NM
EV/R	467.88
EV/Ebitda	NM

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FAQs

What is Upstream Bio, Inc. share price today?

Upstream Bio, Inc. (UPB) share price today is $30.16

Can Indians buy Upstream Bio, Inc. shares?

Yes, Indians can buy shares of Upstream Bio, Inc. (UPB) on Vested. To buy

from India, you can open a US Brokerage account on Vested today by clicking on Sign Up or Invest in UPB stock at the top of this page. The account opening process is completely digital and secure, and takes a few minutes to complete.

Can Fractional shares of Upstream Bio, Inc. be purchased?

Yes, you can purchase fractional shares of Upstream Bio, Inc. (UPB) via the Vested app. You can start investing in Upstream Bio, Inc. (UPB) with a minimum investment of $1.

How to invest in Upstream Bio, Inc. shares from India?

You can invest in shares of Upstream Bio, Inc. (UPB) via Vested in three simple steps:

Click on Sign Up or Invest in UPB stock at the top of this page
Breeze through our fully digital and secure KYC process and open your US Brokerage account in a few minutes
Transfer USD funds to your US Brokerage account and start investing in Upstream Bio, Inc. shares

What is Upstream Bio, Inc. 52-week high and low stock price?

The 52-week high price of Upstream Bio, Inc. (UPB) is $33.68. The 52-week low price of Upstream Bio, Inc. (UPB) is $5.14.

What is Upstream Bio, Inc. price-to-earnings (P/E) ratio?

The price-to-earnings (P/E) ratio of Upstream Bio, Inc. (UPB) is

What is Upstream Bio, Inc. price-to-book (P/B) ratio?

The price-to-book (P/B) ratio of Upstream Bio, Inc. (UPB) is 4.44

What is Upstream Bio, Inc. dividend yield?

The dividend yield of Upstream Bio, Inc. (UPB) is 0.00%

What is the Market Cap of Upstream Bio, Inc.?

The market capitalization of Upstream Bio, Inc. (UPB) is $1.62B

What is Upstream Bio, Inc.'s stock symbol?

The stock symbol (or ticker) of Upstream Bio, Inc. is UPB

How Can Investors Use Upstream Bio, Inc. Share Price Data for Long-Term Investment Decisions?

Consider the share price of Upstream Bio, Inc. as a long-term story and not a daily point list. The price represents a movement of the stock in both good and bad times when looked at over many years. This assists the investors to know whether Upstream Bio, Inc. has succeeded to expand steadily and overcome market declines. With this price movement observed and the way the business is progressing, it is easier to make a decision whether the stock is worth having in the long term or not.

How does USD - INR currency movement impact returns from Upstream Bio, Inc. shares for Indian investors?

When investing in Upstream Bio, Inc. shares, you are not based in India then your investment is not just based on the stock price. It is also determined by the currency movement of the dollar in relation to the rupee. When you have an appreciation of the Upstream Bio, Inc. stock and the dollar appreciation is also the same, you gain more in terms of rupees. When the rupee appreciated, it will lower your profits. This currency flow is a silent cause of great contribution to your ultimate returns over many years.

How should investors compare Upstream Bio, Inc. share price with other stocks in the same sector?

Rather than merely checking the share price of Upstream Bio, Inc. and comparing it with that of other stocks in the same sector, one can check how robust the business is. Investors tend to compare such aspects as profits, cash generation, and the stability of the revenues of the company. This means that Upstream Bio, Inc. stock in most cases does not react in the same manner as other companies in the sector due to its brand and services revenue.

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